眼-耳-脊柱综合征(oculo-auriculo-vertebral spectrum,OAVS),又称Goldenhar综合征、半侧颜面短小(hemifacial microsomia)、眼-耳-脊柱发育不良(facio-auriculo-vertebral spectrum)或面-耳-脊柱发育不良(oculo-auriculo-vertebral dyspla-sia),是由第一、二鳃弓发育不全引起。临床表现复杂多样,典型症状主要为耳廓畸形、下颌骨发育不全、眼畸形包括眼睑缺损和(或)眼球皮样囊肿以及脊柱畸形,也常合并其他畸形如腭裂、唇裂以及 Oculo-auriculo-vertebral spectrum (OAVS), also known as Goldenhar syndrome, hemifacial microsomia, facio-auriculo-vertebral spectrum, or face - Ear - spine dysplasia (oculo-auriculo-vertebral dysplasia), is caused by the first and second branchial hypoplasia. The clinical manifestations are complex and diverse. The typical symptoms are auricle deformity, mandibular hypoplasia, ocular deformities including eyelid defect and / or ocular dermoid cyst and spinal deformity, and other deformities such as cleft palate, cleft lip, and