缺血性脑血管病(ICVD)是一种临床常见病,其发病率、致残率和死亡率均很高。尤其近年来 ICVD有发病率上升及发病年龄年轻化的趋势。近十多年来国内外应用降纤酶治疗 ICVD,已取得了一些进展,而且越来越受到重视。降纤酶的作用机制降纤酶是一种从蛇毒中提取的生物制剂,具有分解纤维蛋白原、抑制血栓形成、诱发组织血浆素原活化素(t-PA)的释放、增强 t-PA、促进纤维蛋白溶酶的生成、减少α_2血浆素抑制物(α_2-PI)和血浆素原抑制物(PAI)以及溶解血栓的作用,还具有降低血黏度、抑制红细胞凝集和沉降、增强红细胞的变 Ischemic cerebrovascular disease (ICVD) is a clinically common disease with high morbidity, morbidity and mortality. In recent years, ICVD has a rising incidence and a younger age of onset. Over the past decade or so domestic and international application of defibrase in the treatment of ICVD, has made some progress, and more and more attention. The mechanism of defibrase Defibrase is a biological preparation extracted from snake venom, which has the ability to decompose fibrinogen, inhibit thrombosis, induce the release of tissue plasminogen activator (t-PA), enhance t-PA, Promote the generation of plasmin, reduce the effect of α_2-PI and PAI and dissolve thrombus, but also reduce the blood viscosity, inhibit the agglutination and deposition of erythrocytes, and enhance the changes of erythrocytes