以L-氨基酸和醇为原料,酸性离子液体辅以少量强酸性阳离子交换树脂作催化剂,直接酯化合成了8种游离的L-氨基酸酯,并用1HNMR对产物进行了表征。通过L-苯丙氨酸正丁酯的合成对离子液体的活性进行了考察,结果表明,所选用的11种离子液体在反应过程中均起到了一定的催化作用和助溶作用。其中,[Hmim][HSO4]效果较好,在重复使用后,显示了较好的稳定性,是氨基酸酯化反应理想的催化剂和助溶剂。 Using L-amino acids and alcohols as raw materials, 8 kinds of free L-amino acid esters were synthesized by direct esterification of acidic ionic liquids with a few strong acid cation exchange resins. The products were characterized by 1HNMR. The activity of ionic liquid was investigated by the synthesis of L-phenylalanine n-butyl ester. The results showed that the 11 ionic liquids used in the reaction all played a catalytic and solubilizing role in the reaction process. Among them, [Hmim] [HSO4] has good effect and shows good stability after repeated use. It is an ideal catalyst and cosolvent for amino acid esterification reaction.