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目的 :探讨心肌酶水平在急性氟乙酰胺中毒患者血清中的变化及临床意义。方法 :对 44例急性氟乙酰胺 (CK ,CK -MB ,AST ,LDH ,α HBDH)中毒者进行连续动态观察。结果 :急性氟乙酰胺中毒患者入院时的心肌酶明显高于对照组 (P <0 0 1) ,中毒后第 1～ 7d血清心肌酶均明显升高 (P <0 0 1) ,第 3～ 7d达到高峰。入院时中、重度中毒患者血清心肌酶明显高于轻度中毒患者 (P <0 0 1) ,重度中毒组与中度中毒组差异也有显著性 (P <0 0 1)。结论 :氟乙酰胺中毒确可引起心肌损害 ,且中毒程度越重 ,心肌酶升高越明显。心肌酶可作为一个判断氟乙酰胺中毒病情变化、预后和指导治疗的重要临床指标
Objective: To investigate the changes and clinical significance of myocardial enzyme levels in serum of patients with acute fluoroacetamide intoxication. Methods: Forty-four acute cases of fluoroacetamide (CK, CK, MB, AST, LDH and α HBDH) were observed continuously and dynamically. Results: Myocardial enzymes in patients with acute fluoroacetamide poisoning were significantly higher than those in control group (P <0.01), serum myocardial enzymes were significantly increased (P <0.01) on the 1st to 7th day after poisoning, 7d reached its peak. Serum myocardial enzymes in patients with moderate or severe poisoning at admission were significantly higher than those with mild poisoning (P <0.01). There was also a significant difference between severe poisoning and moderate poisoning (P <0.01). Conclusion: Fluoroacetamide poisoning can indeed cause myocardial damage, and the more severe poisoning, the more obvious myocardial enzyme increased. Myocardial enzymes can be used as a judgment of fluoroacetamide poisoning disease changes, prognosis and guidance of treatment of important clinical indicators