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在各种免疫防御机制中,IgGFc 受体(FcrR)起着重要作用,其中包括对免疫复合物的吞饮、对抗体包被颗粒的吞噬。此外,FcrR 还控制几种炎性介质的释放。近年,应用不同FcrR 的单克隆抗体在鉴定这些受体和确定其特性方面已取得了很大进展。有三类人FcrR[FcrR1(CD_(64)),FcrRⅡ(CD_(32))和FcrRⅢ(CD_(16))]已从蛋白分子和互补DNA(cDNA)水平上得到确定。人FcrR 的表达和亲合力三类Fcr 受体在类型不同细胞上表达不同,FcrRⅠ持续地表达在人单核细胞和巨噬细胞上。γ干扰素(IFN-γ)可诱导这些细
IgGFc receptor (FcrR) plays an important role in a variety of immune defense mechanisms, including swallowing immune complexes and phagocytosing antibody-coated particles. In addition, FcrR also controls the release of several inflammatory mediators. In recent years, monoclonal antibodies that use different FcrRs have made great progress in identifying these receptors and determining their properties. Three classes of human FcRRs [FcrR1 (CD_ (64)), FcrRII (CD_ (32)) and FcrRIII (CD_ (16)] have been identified from the level of protein molecules and complementary DNA (cDNA) Human FcrR Expression and Affinity The three types of FcR receptors are expressed differently on different types of cells, and FcrRI is consistently expressed on human monocytes and macrophages. Gamma interferon (IFN-γ) can induce these fine