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小脑髓母细胞瘤多发生在儿童期,但近1/5的病例可见于年龄较大的青少年和成人。作者报告了于1960～1979年间所治疗的13例(18%)16岁以上和最近治疗的2例成年病人,并就治疗结果进行讨论。本组病例:男9例,女6例,年龄16～46岁,平均23～2岁,均经组织学检查确诊。手术探查:7例肿瘤位于小脑半球一例,8例肿瘤主要位于中线部位;4例行肿瘤全切,10例行部份切除,1例活检。术后均行全脑脊髓放疗,大部分病人还行后颅凹“增量”放疗,放射总剂量为3000拉德/5周至5000～5500拉德/5～51/2周。其中3例辅以化疗。治疗结果:经随访14个月～16年,放疗后5年成活率为
Pediatric medulloblastoma occurs mostly in childhood, but nearly one-fifth of cases can be seen in older adolescents and adults. The authors reported 13 (18%) of 2 adult patients over the age of 16 and recently treated, who were treated between 1960 and 1979 and discussed the treatment outcome. This group of patients: 9 males and 6 females, aged 16 to 46 years old, an average of 23 to 2 years old, were confirmed by histological examination. Surgical exploration: 7 cases of tumor located in the hemisphere of a cerebellar, 8 cases of tumor mainly in the midline site; 4 cases of total tumor resection, 10 cases of partial resection, 1 case of biopsy. All patients underwent whole brain spinal cord radiotherapy. Most of the patients were also treated with “incremental” radiotherapy of posterior fossa. The total radiation dose was from 3000 rads / 5 weeks to 5000-5500 rad / 5 ~ 51/2 weeks. Three of them were supplemented with chemotherapy. Treatment outcome: After a follow-up of 14 months to 16 years, 5-year survival rate after radiotherapy was