论文部分内容阅读
用6-羟多巴胺损毁大鼠一侧黑质制成帕金森病模型后,在尾状核头部分别移植新鲜的或以每min降低1～2℃的降温速率冷冻贮存的肾上腺髓质组织。术后两实验组动物由阿朴吗啡(apomorphine)诱发的旋转行为较术前有不同程度改善,与对照组相比有显著性差异;两实验组相比较,接受新鲜组织移植组动物平均改善程度优于冷冻贮存移植物组,但无统计学意义。新鲜移植物组移植物荧光强度高于冷冻贮存组,统计学处理两组差异也无显著性。两实验组移植物细胞形态和染色特性无明显不同。
Rat models of Parkinson’s disease were made by destroying the rat substantia nigra with 6-hydroxydopamine, and the adrenal medulla tissue was freshly frozen in the head of caudate nucleus or stored at a cooling rate of 1-2 ° C per min. The rotational behavior induced by apomorphine in the two experimental groups was improved to some extent compared with that before the operation, which was significantly different from the control group. The average improvement degree of the animals in the fresh tissue transplantation group compared with the two experimental groups Better than frozen storage graft group, but not statistically significant. The fluorescence intensity of fresh graft group was higher than that of frozen storage group, and there was no significant difference between the two groups in statistical analysis. The morphology and staining characteristics of the two experimental groups did not differ significantly.