The uniform design and statistical analysis system(SAS) have been employed to study the reaction conditions of graft polymerization of acrylonitrile(AN) onto chitosan using K 2S 2O 8 NaHSO 3 as initiators. The optimum reaction conditions as follows: ω (chitosan)=3.35%, ω (HAc)= 2%, n (AN)/ n (chitosan)=7, n (chitosan)/ n (K 2S 2O 8)=6, n (NaHSO 3)/ n (K 2S 2O 8)=0 538, reaction time 3 5 h, temperature 40 ℃, grafting efficiency being 92 24%. The results showed that the uniform design, as compared with the orthogonal factorization method, has the advantages of timesaving and easier analyse of the influence factors. The uniform design and statistical analysis system (SAS) have been employed to study the reaction conditions of graft polymerization of acrylonitrile (AN) onto chitosan using K 2 SO 2 O 8 NaHSO 3 as initiators. The optimum reaction conditions as follows: ω (chitosan) = 3.35%, ω HAc = 2%, n AN / chitosan = 7, chitosan / n K 2 SO 2 0 8 = 6, n NaHSO 3 / n K 2 SO 2 0 8 ) = 0 538, reaction time 3 5 h, temperature 40 ° C, grafting efficiency being 92 24%. The results showed that the uniform design, as compared with the orthogonal factorization method, has the advantages of timesaving and easier analyze of the influence factors .