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目的探讨冠心病与血清同型半胱氨酸水平之间的关系。方法选择2014年1月至2016年1月冠心病患者115例为研究对象,其中40例为稳定型心绞痛患者(SAP组),75例为急性冠脉综合征患者(ACS组),再选择同期体检健康者80例作为对照组,分别对其进行D-二聚体(D-DT)、血浆纤维蛋白原(FIB)、血清总胆固醇(TC)、超敏C-反应蛋白(hs-CRP)以及血清同型半胱氨酸(Hcy)检测,对比分析三组的检测结果。结果与对照组相比,ASC组和SAP组Hcy、hs-CRP水平均较高,差异有统计学意义(P<0.05);与对照组和SAP组比较,ACS组D-DT、FIB水平均较高,差异有统计学意义(P<0.05);但是对照组与SAP组血清D-DT、FIB水平比较差异未见统计学意义(P>0.05);与对照组比较,SAP组与ACS组高Hcy血症发生率均较高,差异有统计学意义(P<0.05);同时,经多元Logiatic回归分析,结果显示冠心病患者的血清Hcy水平与D-DT、FIB以及hs-CRP呈正相关(P<0.05)。结论高Hcy血症是诱发冠心病的重要危险因素,及时检测血清Hcy水平,有助于预防和治疗冠心病。
Objective To investigate the relationship between coronary heart disease and serum homocysteine levels. Methods One hundred and fifteen patients with coronary heart disease were selected from January 2014 to January 2016. Forty patients with stable angina pectoris (SAP group) and 75 patients with acute coronary syndrome (ACS group) Eighty healthy people were selected as the control group, and their D-DT, FIB, TC, hs-CRP, And serum homocysteine (Hcy) test, comparative analysis of the three groups of test results. Results Compared with control group, the levels of Hcy and hs-CRP in ASC group and SAP group were significantly higher than those in control group (P <0.05). Compared with control group and SAP group, the levels of D-DT and FIB (P <0.05). However, there was no significant difference in the serum D-DT and FIB levels between the control group and the SAP group (P> 0.05). Compared with the control group, Hcy hyperlipidemia was significantly higher (P <0.05). At the same time, multivariate logistic regression analysis showed that serum Hcy level was positively correlated with D-DT, FIB and hs-CRP in patients with coronary heart disease (P <0.05). Conclusions Hyperhomocysteinemia is an important risk factor for coronary heart disease. Serum Hcy level can be measured in time to prevent and treat coronary heart disease.