病人男,42岁。眼睑、双下肢膝关节以下水肿5年,尿检异常1 d。双侧眼睑、双下肢膝关节以下水肿为凹陷性,自觉尿量减少,伴有轻度腹胀。无其他明显阳性体征、症状。入院后查尿常规示:白细胞(+),管型颗粒(+++),尿蛋白(+++);血常规:白细胞9.33×10~9/L,血红蛋白138g/L,血小板227×10~9/L;血沉60 mm/h,纤维蛋白原含量6.36g/L。24 h尿蛋白3.96g,肌酐122μmol/L,尿素氮11 mmol/L,白蛋白16.1 Male patient, 42 years old. Eyelid, lower extremity below the knee joint edema 5 years, urine abnormalities 1 d. Bilateral eyelids, lower extremity below the knee joint edema was depressed, decreased spontaneous urine, accompanied by mild abdominal distension. No other obvious positive signs and symptoms. Urine routine examination after admission showed: white blood cells (+), tubular particles (+++), urinary protein (+++); blood: white blood cells 9.33 × 10 ~ 9 / L, hemoglobin 138g / L, platelets 227 × 10 ~ 9 / L; ESR 60 mm / h, fibrinogen content 6.36g / L. 24 h urinary protein 3.96 g, creatinine 122 μmol / L, urea nitrogen 11 mmol / L, albumin 16.1