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为了解人类血清和肠道分泌液中IgA间的关系,作者选择19～52岁,无伤寒病史和免疫史的健康志愿者20名,分成3组。第1组和第2组各7人,每隔48小时口服1剂(共3剂)Ty21a冻干活菌苗,每次10~(11)个菌。第1组观察3周,而第2组观察6周;第3组6人于0和14天皮下注射市售死菌苗各1次,每次0.5×10~9个菌,于33、35和48天各口服1剂Ty21a活菌苗,剂量与1和2组相同。免疫前后采肠液及血清,用ELISA检测
To understand the relationship between human serum and IgA in intestinal secretions, the authors selected 20 healthy volunteers aged 19 to 52 years with no history of and history of immunization and divided them into 3 groups. Groups 1 and 2 each consisted of Ty21a lyophilized live vaccine, 10 to 11 (11) bacteria, orally in one dose (3 doses) every 48 hours. Group 1 was observed for 3 weeks while Group 2 was observed for 6 weeks. Group 3 was injected subcutaneously with 1 × 10-9 commercially available killed vaccines at 0 and 14 days, And 48 days of oral administration of a single dose of Ty21a live vaccine, the same dose and 1 and 2 groups. Before and after immunization, intestinal juice and serum were collected and tested by ELISA