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为提高人口素质,预防出生缺陷的发生。我们根据甘肃地理特点及经济状况,按随机分层整群抽样方法,抽取当地出生的5岁内婴幼儿作为调查对象。以出生缺陷患儿为病例组,以同年、同性别、居住地相近的正常儿作为对照,对其家庭进行调查。结果显示甘肃省不同地区出生缺陷共有的易患因素为:母亲孕早期服药史;母亲孕早期感染史;父亲年龄在35岁以上亦是产生出生缺陷的危险因素。提示实施出生缺陷干预工程应大力进行孕前、孕早健康教育,深化优生指导,以达到降低出生缺陷发生率的目的。
In order to improve the quality of the population, prevent birth defects. According to the geographic characteristics and economic conditions of Gansu, we randomly selected stratified cluster sampling methods to collect locally-born 5-year-old infants and young children as the survey subjects. The cases of children with birth defects were selected as the controls, and their families were investigated with normal children of the same age, same sex and residence. The results showed that the common risk factors of birth defects in different areas of Gansu province were: the mother’s medication history during the first trimester of pregnancy; the mother’s infection history during the first trimester; father’s age over 35 years old was also a risk factor for birth defects. Prompt implementation of birth defects intervention project should vigorously carry out pre-pregnancy and premature pregnancy health education, deepen the guidance of eugenics in order to achieve the purpose of reducing the incidence of birth defects.