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目的:探讨米非司酮配伍依沙吖啶用于中期引产的临床效果。方法:将自愿要求终止妊娠的患者119例随机分为观察组和对照组。对照组检查结果无异常直接行利凡诺羊膜腔穿刺引产术;观察组当天或第2天下午16点口服米非司酮片75 mg,晚12:00点口服米非司酮片75 mg,次日晨8点、下午16点、晚12:00点各口服米非司酮片50 mg,服药第2天羊膜腔内注入依沙吖啶100 mg,服药前后2 h空腹。观察两组的宫缩发动时间、宫缩发动到生产的时间、残留率有无区别。结果:观察组平均宫缩发动时间为(23.48±11.43)h,对照组平均宫缩发动时间为(34.33±12.25)h,两组差异有统计学意义(P<0.05);观察组宫缩发动到生产时间为(5.27±4.35)h,对照组宫缩发动到生产时间为(11.21±6.32)h,两组差异有统计学意义(P<0.05)。观察组残留率为16.67%,对照组残留率为32.20%,两组差异有统计学意义(P<0.05)。结论:米非司酮联用依沙吖啶终止中期妊娠比传统的单用依沙吖啶可缩短宫缩发动到生产的时间,降低产后刮宫率,减轻患者痛苦,缩短住院天数,减轻患者经济负担。
Objective: To investigate the clinical effect of mifepristone combined with ethacridine for mid-term induction of labor. Methods: 119 patients who volunteered for termination of pregnancy were randomly divided into observation group and control group. In the control group, no abnormalities were found, and Rivhenol amniocentesis was performed directly. On the day of the observation group or on the second day, the mifepristone tablets were given at 75 o’clock in the afternoon or at 16 o’clock on the second day, 75 mg of mifepristone tablets were orally taken at 12:00 o’clock, The next morning at 8 am, 16 pm, 12:00 pm orally mifepristone tablets 50 mg, intramuscular injection of ethacridine 100 mg on the second day of medication, fasting 2 h before and after taking the drug. Observation of two groups of contractions start time, uterine contractions to the time of production, the residual rate whether the difference. Results: The average duration of uterine contractions was (23.48 ± 11.43) h in the observation group and (34.33 ± 12.25) h in the control group, with significant difference between the two groups (P <0.05) (5.27 ± 4.35) h in the control group and (11.21 ± 6.32) h in the control group. The difference between the two groups was statistically significant (P <0.05). The residual rate of the observation group was 16.67%, the control group residual rate was 32.20%, the difference between the two groups was statistically significant (P <0.05). Conclusion: Mifepristone combined with Ethacridine termination of the second trimester pregnancy than the traditional single use of Ethacridine can shorten the time to start the production of uterine contraction, reduce the rate of postpartum curettage, reduce patient pain, shorten the length of stay, reduce the patient’s economy burden.