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目的检测结核病患者血浆纤维蛋白原、D-二聚体及血小板水平,探讨其临床意义。方法分别检测了120例肺结核(肺结核组)患者、120例结核性胸膜炎患者(结核性胸膜炎组)和60例健康对照者(对照组)血浆纤维蛋白原、D-二聚体水平,分析3组间凝血指标的差异。结果肺结核组及结核性胸膜炎组的血浆纤维蛋白原、D-二聚体水平明显高于对照组,差异有统计学意义(P<0.01);结核性胸膜炎组的纤维蛋白原、D-二聚体及血小板水平明显高于肺结核组,差异有统计学意义(P<0.01);结核性胸膜炎组的血小板水平比对照组高,差异有统计学意义(P<0.05)。结论结核病患者体内存在高凝状态,特别是结核性胸膜炎患者,易形成血栓性疾病,监测凝血相关指标,对预防血栓性并发症有重要临床意义。
Objective To detect plasma fibrinogen, D-dimer and platelet in patients with tuberculosis and to explore its clinical significance. Methods The levels of plasma fibrinogen and D-dimer in 120 patients with tuberculosis (tuberculosis), 120 patients with tuberculous pleurisy (tuberculous pleurisy) and 60 healthy controls (control group) Differences between the indicators of coagulation. Results The levels of fibrinogen and D-dimer in tuberculosis group and tuberculous pleurisy group were significantly higher than those in control group (P <0.01). The levels of fibrinogen, D-dimer in tuberculous pleurisy group (P <0.01). The level of platelet in tuberculous pleurisy group was higher than that in control group (P <0.05). Conclusion There is a hypercoagulable state in tuberculosis patients, especially in patients with tuberculous pleurisy. It is easy to form thrombotic diseases and to monitor indicators related to coagulation. It has important clinical significance in preventing thrombotic complications.