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顺氯氨铂(cisplatin,下简称DDP),系一种新型广谱抗癌药.1965年Rosenberg发现其抗癌作用;1969年首次应用于临床;1976年开始用于骨肉瘤的治疗;证实DDP对骨与软组织恶性肿瘤,特别是用大剂量甲氨喋呤、阿霉素等治疗无效,进而发生肺转移的晚期骨肉瘤也有一定疗效。国内有关这方面的报道甚少。 我院85年3月至86年5月,采用DDP化疗配合手术治疗骨与软组织恶性肿瘤11例,16人次,初步报告如下。
Cisplatin (hereinafter referred to as DDP) is a novel broad-spectrum anticancer drug. Rosenberg discovered its anti-cancer effect in 1965; it was first used clinically in 1969; it began to be used for the treatment of osteosarcoma in 1976; For bone and soft tissue malignancies, especially with large doses of methotrexate, doxorubicin and other treatment is invalid, and then the occurrence of lung metastasis of advanced osteosarcoma has a certain effect. There are very few domestic reports on this issue. In our hospital from March of 1998 to May of 2009, 11 cases of bone and soft tissue malignancy were treated with DDP chemotherapy combined with surgery. The preliminary report was as follows.