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目的 探讨模拟间断性人工重力刺激对抗模拟失重下大鼠脑基底动脉血管反应性改变的效果。 方法 雄性 SD大鼠 35只 ,按体重随机分为 5组 ,即 :1同步对照组 ;2模拟失重组 (3周尾部悬吊 ) ;3模拟失重 +站立位 4h组 ;4模拟失重 +站立位 2 h组 ;5模拟失重 +站立位 1h组。每组7只。每日分别给予站立组大鼠不同持续时间 (1h,2 h或 4h)的站立位 (STD) ,测定大鼠离体基底动脉血管环对 KCl的收缩反应性。 结果 悬吊组大鼠基底动脉血管环对 KCl的最大反应较对照组显著升高 (P<0 .0 5 ) ;STD组大鼠基底动脉血管环对 KCl的最大反应较悬吊组显著减弱 (P<0 .0 5 ) ,与对照组无显著差别。 结论 每日给予尾部悬吊大鼠最少 1h模拟人工重力刺激可对抗模拟失重对大鼠脑动脉血管反应性的影响
Objective To investigate the effect of simulated intermittent artificial gravitational stimulation on vascular reactivity changes of basilar artery in rats under simulated weightlessness. METHODS: Thirty-five male Sprague-Dawley rats were randomly divided into five groups according to body weight: 1 synchronous control group, 2 simulated weightlessness group (3 weeks tail suspension), 3 simulated weightlessness and standing 4h group, 4 simulated weightlessness and standing position 2 h group; 5 simulated weightlessness + standing position 1h group. 7 per group The standing position (STD) of rats in standing group was given daily for different durations (1h, 2h or 4h), and the contractile response of isolated basilar artery rings to KCl was measured. Results The maximal response of basilar artery rings of suspension group to KCl was significantly higher than that of control group (P <0.05). The maximal response of basilar artery rings of STD rats to KCl group was significantly weaker than that of suspension group P <0. 05), no significant difference with the control group. CONCLUSION: The simulated daily artificial gravity stimulation of tail-suspended rats at least every 1h can counteract the effects of simulated weightlessness on the cerebral arterial reactivity in rats