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自1975年Cimetidine在消化性溃疡病治疗中应用以来,H_2受体阴滞剂在溃疡病治疗中占有重要地位,尤其是Ranitidine疗效更高,副作用更小,临床应用更广,但由于夏发率较高.使部分患者长期服用,一旦停药就出现泛酸症状,而胃镜检查未发现溃疡病灶,再服Ranitidine症状即可缓解.本文就这部分患者进行了临床分析,认为这种现象是H_2受体阻滞剂依赖现象,初步探讨了其发生机理和临床意义.
Since 1975, Cimetidine in the treatment of peptic ulcer disease, H 2 receptor antagonist plays an important role in the treatment of ulcer disease, especially Ranitidine more effective, less side effects, clinical application of a wider, but due to summer hair rate So that some patients long-term use, once the withdrawal of symptoms of pantothenic acid, and gastroscopy found no ulcer lesions, and then serving Ranitidine symptoms can be alleviated.This part of the clinical analysis of patients, that this phenomenon is H_2 by Body blockers rely on the phenomenon, initially explored its mechanism of occurrence and clinical significance.