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目的:观察2-甲氧基雌二醇(2-methoxyestradiol,2-ME)灌胃给药的小鼠急性毒性反应。方法:经预试确定按最大给药量法设计试验,小鼠40只,♀♂各半,随机分为给药组和阴性对照组,给药组以2-ME2 000 mg.kg-1为最大给药剂量,40mL.kg-1为最大给药容量,在24 h内一次灌胃,阴性对照组以等容积的纯化水一次灌胃,给药后自由饮食饮水,连续2周观察小鼠体质量、行为活动以及死亡情况。结果:给药组小鼠观察期间内体质量及行为活动异常无变化,未见死亡。结论:2-ME灌胃给药对小鼠急性毒性甚低,提示该药为低毒化学物。
Objective: To observe the acute toxicity of 2-methoxyestradiol (2-ME) intragastric administration in mice. Methods: After the pre-test to determine the maximum dose method designed to test 40 mice, ♀ ♂ half, were randomly divided into the administration group and the negative control group, the administration group to 2-ME2 000 mg.kg-1 The maximum dose, 40mL.kg-1 for the maximum drug delivery capacity, intragastric gavage within 24 h, the negative control group with an equal volume of purified water once gavage, free diet after administration of water, mice were observed for 2 weeks Weight, behavior and death. Results: There was no change in body mass and behavioral activity during the observation period in mice in the administration group, and no death was observed. Conclusion: 2-ME intragastric administration of acute toxicity in mice is very low, suggesting that the drug is low toxic chemicals.