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为评价航天特因环境下脑的功能状态，研究了噪声与模拟失重复合因素作用对豚鼠脑干听觉诱发电位（ＢＡＥＤ）的影响。实验分为噪声与头低位－３０°组、噪声与头低位０°组、噪声组和头低位－３０°组。使用８０ｄＢ（Ａ）白噪声声场，连续实验８昼夜。每隔２４ｈ记录用短声（ｃｌｉｃｋ）诱发的ＢＡＥＰ。结果表明，在噪声与头低位－３０°复合作用下，ＢＡＥＰ各波潜伏期较实验前有明显的增加趋势，以Ⅰ、Ⅲ波最为显著。Ⅲ－Ⅴ、Ⅰ－Ⅴ峰间期亦有一定的增加趋势。上述改变在作用第３、４ｄ最为严重。但随着作用时间的延续，各参量有恢复的趋势。单纯的噪声作用及噪声与头低位０°复合作用对动物ＢＡＥＰ无明显影响。而头低位－３０°本身对ＢＡＥＰ影响极为显著。作用８ｄ过程中，各波峰潜伏期及Ⅰ－Ⅲ峰间期均出现显著性增加。这说明，８０ｄＢ（Ａ）噪声连续作用对脑干部分听觉通路的生理状态影响不大；在模拟失重时，机体脑干听觉功能有所下降，并在８ｄ实验中经历一个适应过程；而在噪声与头低位－３０°复合因素时，头低位－３０°的作用是主导的，噪声是次要的因素。提示，ＢＡＥＰ可以作为评价航天特因环境下脑功能状态的一种有效的手段。
In order to evaluate the functional status of brain under aerospace special enviroment, the effects of noise and simulated weightlessness on brainstem auditory evoked potential (BAED) in guinea pigs were studied. The experiment was divided into noise and head low -30 ° group, noise and head low 0 ° group, noise group and head low -30 ° group. Use 80dB (A) white noise sound field, continuous experiment 8 days and nights. BAEP evoked by click was recorded every 24h. The results show that under the combined effect of noise and head depression of -30 °, the latency of each wave of BAEP is obviously increased compared with that before experiment, and the waves of Ⅰ and Ⅲ are the most obvious. Ⅲ-Ⅴ, Ⅰ-Ⅴ peak interval also have a certain increase trend. The above changes in the role of the first 3,4d the most serious. However, with the continuation of the role of time, the parameters have the tendency to recover. Pure noise and noise combined with 0 ° low head had no significant effect on BAEP. The head low of -30 ° itself has a significant impact on BAEP. During the course of 8 days, the peak latency and the peak period of Ⅰ-Ⅲ peaked obviously. This shows that the continuous effect of 80dB (A) noise has little effect on the physiological status of some auditory pathways in brainstem; during the simulated weightlessness, the brainstem auditory function of the body decreased, and undergone an adaptation process in 8d experiments; When combined with a head low of -30 °, head-down -30 ° dominates and noise is a secondary factor. It is suggested that BAEP can be used as an effective measure to evaluate the state of brain function under the special environment of space flight.