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目的观察卡维地洛联合螺内酯治疗慢性心力衰竭的近期疗效。方法将慢性心力衰竭患者94例随机分为观察组和对照组,每组47例。观察组在常规综合治疗的基础上给予卡维地洛联合螺内酯治疗,对照组采用常规综合疗法,对比2组患者治疗效果和治疗前后6min步行距离、心率变化。结果观察组总有效率为97.9%高于对照组的70.2%,治疗后2组心率明显低于治疗前,6min步行距离远于治疗前,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论卡维地洛联合螺内酯治疗慢性心力衰竭的近期疗效显著,可明显改善患者心功能、心率和活动能力,值得临床推广应用。
Objective To observe the short-term effect of carvedilol combined with spironolactone in the treatment of chronic heart failure. Methods 94 patients with chronic heart failure were randomly divided into observation group and control group, 47 cases in each group. The observation group was given carvedilol combined with spironolactone on the basis of conventional comprehensive treatment. The control group was treated with conventional combination therapy. The treatment effect and the walking distance and heart rate at 6min before and after treatment were compared. Results The total effective rate in the observation group was 97.9%, which was higher than that in the control group (70.2%). After treatment, the heart rate in 2 groups was significantly lower than that before treatment and 6 minutes walking distance before treatment, and the changes in observation group were more than those in control group Significance (P <0.05). Conclusion Carvedilol combined with spironolactone in the treatment of chronic heart failure in the short term effect is significant, can significantly improve the patient’s cardiac function, heart rate and activity, it is worthy of clinical application.