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根据胆酸性利胆剂可增加胆汁BSP_(Tm)而非胆酸性利胆剂则否的原理,在22例已行胆囊切除、胆总管“T”管引流的胆石症病人中,静脉大剂量滴注BSP,当达胆汁BSP_(Tm)时,实验组10例,从另一静脉滴注中药利胆剂“菌陈胆道汤”,对照组12例则静脉滴注5％葡萄糖溶液。分别收集“T”管胆汁行生化测定。结果,胆汁BSP_(Tm)仅与胆汁中胆酸及BSP浓度有关,而与胆汁流量无关。静脉滴注“菌陈胆道汤”后,胆汁BSP_(Tm)不增加。静脉大剂量注射BSP对胆汁中胆酸、钾、钠、氯、碳酸氢根离子、pH及胆汁流量均无明显影响。所有受试者均无不良反应。提示,“T”管胆汁BSP_(Tm)测定可用作探讨中药利胆剂利胆机理的观察方法之一。
According to the principle that cholic acid gallbladder can increase BSP_ (Tm) rather than bile acid choleretic, in 22 cases of cholelithiasis patients undergoing cholecystectomy and common bile duct “T” tube drainage, large intravenous drip Note BSP, when the bile BSP_ (Tm), the experimental group of 10 cases, from another intravenous infusion of Chinese medicine gallbladder “Chen Chen biliary soup”, while the control group, 12 cases, intravenous infusion of 5% glucose solution. Biochemical tests were performed on “T” tube bile line. As a result, bile BSP_ (Tm) was only related to cholic acid and BSP concentrations in bile, regardless of bile flow. After intravenous instillation of “bacterial Chen biliary soup”, the BSP_ (Tm) did not increase. Intravenous bolus injection of BSP had no significant effect on bile cholic acid, potassium, sodium, chloride, bicarbonate ion, pH and bile flux. All subjects had no adverse reactions. Tip, “T” tube BSP Tm determination can be used as a method to explore the gallbladder gallbladder mechanism of observation.