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近年来生长抑素长效激动剂SMS201-995(SMS)已初步由于临床治疗某些难治性疾病如肢端肥大症(肢大)、糖尿病、胃肠胰内分泌肿瘤等并取得显著的疗效。我们曾用SMS治疗肢大20例,发现所有患者的胆囊收缩功能均被显著抑制,其中部分患者伴有胆囊结石的形成。为了探索防治SMS引起胆囊病变的方法,本实验观察小剂量SMS对正常人胆囊收缩功能的影响。受试者为6例健康成人,男女各3例,平均年龄31.8岁,每隔一周皮下注射SMS50、25、12.55μg后观察受试者胆囊收缩功能的变化。以脂餐试验结合胆囊B超声检查为主要方法。结果未注射SMS
In recent years, somatostatin long-acting agonist SMS201-995 (SMS) has been initially due to the clinical treatment of certain refractory diseases such as acromegaly (limbs), diabetes, gastrointestinal pancreatic endocrine tumors and achieved significant results. We used to treat 20 cases of limbs with SMS, found that all patients were significantly inhibited gallbladder contractility, some patients with gallstone formation. In order to explore the prevention and treatment of SMS-induced gallbladder disease, this experiment observed small doses of SMS on the normal human gallbladder contraction function. Subjects were 6 healthy adults, 3 males and 3 females, average age of 31.8 years old, every other week subcutaneously injected SMS50,25,12.55 g after the observation of changes in patients with gallbladder contractility. Fat meal test with gallbladder B ultrasound as the main method. The results were not injected SMS