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Being a great revolution of medical research, translational medicine tries to establish more directly linkage between the basic research and clinical medical treatment-two-sideway translational channel so as to quickly promote the clinical transformation and feedback of basic research achievements. So far, A lot of effective studies on translational medicine in various medical ifelds at home and abroad have been carried out,such as tumor, cardiocerebral vascular diseases, obesity, respiratory functional disorder, epilepsy, schizophrenia, organ transplantation, clinical application of stem cells and neural restoration, meanwhile, many fruitful studies on translational medicine are also performed or being performed in different disciplines or professions, and achieves better progress. But many problems are also presented. Therefore, the direction of medical development in 21 century should be fostering the concepts of translational medicine, encouraging the bidirectional cross between basic research staff and clinical doctors as well as focusing on translational achievements and practical application.