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目的分析糖尿病、非糖尿病患者糖化血红蛋白(HbA1c)水平与冠心病发病的相关性。方法选取2010年10月至2012年8月安阳市第三人民医院拟诊为冠心病的378例糖尿病患者及198例非糖尿病者作为研究对象,所有研究对象均行冠状动脉造影检查,确诊为冠心病组292例,非冠心病组284例。测量HbA1c水平,分析冠心病与HbA1c水平的相关性。结果冠心病组HbA1c、餐后2h血糖、空腹血糖、高密度脂蛋白(HDL-C)、尿酸水平均高于非冠心病组(P<0.05),Logistic回归分析HDL-C、HbA1c是冠心病的独立危险因素;HbA1c≥6%者冠心病发病率高于HbA1c<6%者,差异有统计学意义(P<0.01)。结论 HbA1c是冠心病发病的独立危险因素,可作为冠心病诊断的可靠标准。
Objective To analyze the correlation between the level of HbA1c in diabetic and non-diabetic patients and the incidence of coronary heart disease. Methods A total of 378 diabetic patients and 198 non-diabetic patients who were diagnosed as coronary heart disease in Anyang Third People’s Hospital from October 2010 to August 2012 were selected as study subjects. All subjects underwent coronary angiography and were diagnosed as coronary 292 cases of heart disease group, 284 cases of non-coronary heart disease group. The level of HbA1c was measured and the correlation between coronary heart disease and HbA1c level was analyzed. Results HbA1c, 2h postprandial blood glucose, fasting blood glucose, high density lipoprotein (HDL-C) and uric acid in CHD group were significantly higher than those in non-CHD group (P <0.05). Logistic regression analysis showed that HDL-C and HbA1c were coronary heart disease The independent risk factors of HbA1c≥6% were higher than those with HbA1c <6%, the difference was statistically significant (P <0.01). Conclusion HbA1c is an independent risk factor for coronary heart disease, which can be used as a reliable standard for the diagnosis of coronary heart disease.