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甲硝唑(Metronidagole)作为抗厌氧菌的首选药物临床报道资料众多,本文收集一部分有关其药代动力学、相互作用等资料以供读者参考。一、药动学资料甲硝唑口服吸收迅速,1h吸收80％。达峰浓度在2～3h,持续有效浓度在12h以上。一次服200mg剂量后至8h,血药浓度在20～4μg/ml之间波动;多次给药后稳态血浓度在3d内达到,静脉滴注500mg,每隔8h一次,测得稳态浓度的平均峰谷为28.5μg/ml (0.5h)和16μg/ml(7.5h)(甲硝唑对大多数敏感厌氧菌的MIC为1～8μg/ml).若与食物同服,可使血峰浓度迟1～2h,
Metronidazole (Metronidagole) as anti-anaerobic drug of choice for clinical reports of many, this collection of part of the pharmacokinetics, interactions and other information for readers reference. First, the pharmacokinetics of metronidazole oral absorption quickly, 1h absorption of 80%. Peak concentration of 2 ~ 3h, sustained effective concentration of 12h or more. After a dose of 200mg to 8h, plasma concentration fluctuated between 20 ~ 4μg / ml; after multiple administration of steady-state blood concentration reached within 3d, intravenous infusion of 500mg, once every 8h, measured steady-state concentration Average peak trough was 28.5 μg / ml (0.5 h) and 16 μg / ml (7.5 h) (metronidazole for most sensitive anaerobic bacteria MIC 1 ~ 8μg / ml.) If the same service with food, you can make Blood peak concentration late 1 ~ 2h,