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目的分析承德市2014年新生儿接种乙肝疫苗疑似预防接种异常反应的发生特征,评价接种乙肝疫苗的安全性。方法通过全国疑似预防接种异常反应(AEFI)监测信息管理系统,收集承德市乙肝疫苗常规免疫接种后AEFI病例数据,采用描述性方法对相关指标进行流行病学分析。结果 2014年承德市接种乙肝疫苗共115 205剂次,报告AEFI病例32例,报告发生率为277.77/100万剂;男女性别比为2.2∶1。一般反应占96.88%,其中84.38%发生在接种后≤1 d;异常反应占3.13%。临床损害居前3位为发热、红肿和疼痛等,其次为过敏性皮疹(8.68/100万剂)。结论接种乙肝疫苗具有良好的安全性,不良反应发生率低。
Objective To analyze the occurrence of suspected abnormal immunization of newborns with hepatitis B vaccine in Chengde City in 2014 to evaluate the safety of hepatitis B vaccine. Methods AEFI monitoring information management system was used to collect data of AEFI cases after routine immunization of hepatitis B vaccine in Chengde City. The descriptive method was used to carry out epidemiological analysis of related indicators. Results A total of 115 205 doses of Hepatitis B vaccine were vaccinated in Chengde City in 2014. 32 AEFI cases were reported, with a reported incidence of 277.77 / 100 million doses. The sex ratio was 2.2: 1. The general reaction accounted for 96.88%, of which 84.38% occurred after inoculation ≤ 1 d; abnormal reaction accounted for 3.13%. The top three clinical lesions were fever, redness and pain, followed by an allergic skin rash (8.68 / 1 million doses). Conclusion Hepatitis B vaccination has good safety and low incidence of adverse reactions.