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本文报道了人主动脉壁中正常及异常(脂纹,FS)区的三种蛋白聚糖(PG)即:硫酸软骨素PG(CSPG)、硫酸皮肤素—硫酸软骨素PG(DSCSPG)及硫酸乙酰肝素PG(HSPG)与血清极低密度脂蛋白(VLDL)及低密度脂蛋白(LDL)所形成的不溶性复合物。在30mmol/L Ca~(2+)对,三种PG都能与这两种脂蛋白形成不溶性复合物,随放置时间的增加,形成的复合物都发生解离,但其复合物形成的曲线及解离程度明显不同。DSCSPG与CSPG比较,前者与两种脂蛋白更易形成不溶性复合物且不易解离。HSPG与两种脂蛋白形成不溶性复合物所需时间远大于CSPG及DSCSPG。FS区及正常区三种PG形成复合物曲线类型相似,异常区CSPG、DSCSPG与VLDL形成的复合物量低于正常区的相应PG,而与VLDL则高于正常区的相应PG。异常区的HSPG与两种脂蛋白形成不溶性复合物的量均高于正常区。
In this paper, three proteoglycans (PGs), namely, chondroitin sulfate (PG), dermatan sulfate - chondroitin sulfate PG (DSCSPG) and normal acid Insoluble complexes of heparan PG (HSPG) with serum VLDL and low density lipoprotein (LDL). In the 30 mmol / L Ca 2+ pair, all three PGs could form insoluble complexes with these two lipoproteins, and the complexes formed dissociated with increasing the storage time, but the complex formation curve And the dissociation degree is obviously different. DSCSPG compared with CSPG, the former with two lipoproteins easier to form insoluble complexes and not easy to dissociate. The time required for HSPG to form insoluble complexes with both lipoproteins is much greater than for CSPG and DSCSPG. The complex types of PG formation complexes in FS area and normal area were similar. The amount of complex formed by CSPG, DSCSPG and VLDL in abnormal area was lower than that in normal area, but higher than VLDL in normal area. The amount of insoluble complexes between HSPG and two lipoproteins in the abnormal region were higher than those in the normal region.