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目的分析急性血吸虫病确诊病例间接血凝试验(IHA)检测抗体滴度效价,为诊断与治疗急性血吸虫病提供依据。方法以2001年以来收治住院的135例急性血吸虫病确诊病例为观察对象。采集病人基本情况,询问疫水接触情况等,并进行IHA抗体滴度效价检测,比较不同年龄、潜伏期与住院天数之间的相关性。结果 135例病例中IHA检测抗体滴度均>1∶320,其中滴度1∶640、1∶1 280、1∶2 560、1∶5 120、1∶10 240分别占1.48%、28.15%、35.56%、20.00%、14.81%。急性感染病例的平均年龄47.70±14.58岁,平均潜伏期38.03±4.59 d,平均住院时间15.08±3.79 d。抗体滴度效价与年龄分布无相关性(r=0.109,P>0.05),差异无统计学意义(F=0.64,P>0.05),但与潜伏期呈负相关(r=-0.558,P<0.01)、住院时间呈正相关(r=0.791,P<0.01),各组差异均有统计学意义(F=17.07、64.53,P均<0.01)。结论 IHA检测急性血吸虫病例抗体滴度效价均在1∶640及以上,抗体滴度效价与年龄大小无相关性,抗体滴度效价高者,血吸虫病潜伏期短、住院时间长。
Objective To analyze the titers of antibody titer detected by indirect hemagglutination test (IHA) in diagnosed cases of acute schistosomiasis and provide basis for diagnosis and treatment of acute schistosomiasis. Methods The 135 confirmed cases of acute schistosomiasis admitted to hospital since 2001 were observed. Collect the basic information of the patients, inquire about the contact of the infected water, etc., and detect the titer of IHA antibody titer, and compare the correlation between different ages, incubation period and hospitalization days. Results The titer of IHA antibody was> 1: 320 in 135 cases, of which the titer was 1: 640, 1: 280, 2: 560, 1: 5 120 and 1:40 240 were 1.48% and 28.15% 35.56%, 20.00%, 14.81%. The average age of acute infection cases was 47.70 ± 14.58 years with an average incubation period of 38.03 ± 4.59 days and an average length of stay of 15.08 ± 3.79 days. There was no significant correlation between antibody titer and age distribution (r = 0.109, P> 0.05), but the difference was not statistically significant (F = 0.64, P> 0.05) 0.01) and hospital stay (r = 0.791, P <0.01). There were significant differences among the groups (F = 17.07, 64.53, P <0.01). Conclusion The titer of antibody titers of IHA in acute schistosomiasis patients are all above 1: 640 and above. There is no correlation between titer of antibody titers and age, high titers of antibody titers, short incubation period of schistosomiasis and long hospital stay.