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慢性阻塞性肺疾病是呼吸系统常见慢性疾病。该疾病的发病与环境及多基因变异有关。近年的研究显示,人音猬因子相互作用蛋白基因参与多个系统疾病的发生发展,尤其对于呼吸系统该基因与慢性阻塞性肺疾病发病密切相关,该基因上某些单核苷酸多态性与慢性阻塞性肺疾病易感性相关,且在慢性阻塞性肺疾病患者肺组织内存在该基因低表达。另外,该基因与FEV1和FEV1/FVC关系密切,对肺功能有保护作用。目前的研究提示该基因和音猬信号通路在肺胚胎发育、基因表达调控、细胞增殖、细胞凋亡和平滑肌修复等方面发挥着重要调控作用,为慢性阻塞性肺疾病发病机制的研究指明了方向。本文就人音猬因子相互作用蛋白基因与慢性阻塞性肺疾病相关性的研究进展作一综述。
Chronic obstructive pulmonary disease is a common chronic disease of the respiratory system. The incidence of the disease and the environment and multi-gene variation. Recent studies have shown that the gene of the human sphingon factor interacting protein is involved in the development of many systemic diseases, especially for the respiratory system. The gene is closely related to the pathogenesis of chronic obstructive pulmonary disease. Some single nucleotide polymorphisms It is associated with the susceptibility to chronic obstructive pulmonary disease and exists in the lung tissue of patients with chronic obstructive pulmonary disease. In addition, the gene is closely related to FEV1 and FEV1 / FVC and has a protective effect on lung function. The current study suggests that the gene and sonic hedgehog signaling pathways play an important regulatory role in the development of lung embryo, gene expression regulation, cell proliferation, apoptosis and smooth muscle repair, pointing out the direction for the study of the pathogenesis of chronic obstructive pulmonary disease. This review summarizes the progress of the research on the relationship between the genes of human sphincter interacting proteins and chronic obstructive pulmonary disease.