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目的分析米索前列醇治疗产后出血的临床效果并进行药理分析。方法 120例初次妊娠产妇,随机分为实验组和参照组,各60例。实验组经口服、直肠、阴道给药米索前列醇治疗,参照组静脉注射缩宫素治疗。比较两组治疗止血效果及不同的给药方式的止血效果。结果经治疗,实验组患者血压,产程,产后2、24 h出血量均优于参照组,差异有统计学意义(P<0.05)。实验组分别经口服、直肠以及阴道三种途径给予米索前列醇治疗后,产妇血压、产程、出血情况比较,差异无统计学意义(P>0.05)。结论米索前列醇能够有效控制产妇产后出血,起效快且安全性高。
Objective To analyze the clinical effect of misoprostol in treating postpartum hemorrhage and analyze its pharmacology. Methods 120 cases of first trimester pregnant women were randomly divided into experimental group and reference group, each 60 cases. The experimental group was treated with misoprostol orally, rectally and vaginally, and the reference group was treated with oxytocin intravenously. The effect of hemostasis and the way of hemostasis were compared between the two groups. Results After treatment, blood pressure, labor duration and blood loss in experimental group were better than those in reference group at 2 and 24 hours after delivery. The difference was statistically significant (P <0.05). There was no significant difference in the blood pressure, labor process and bleeding among the experimental group treated with misoprostol orally, rectally and vaginally (P> 0.05). Conclusion Misoprostol can effectively control maternal postpartum hemorrhage with fast onset and high safety.