胰岛素水溶性受体蛋白和大部分水溶性膜蛋白,在较高浓度的螯合剂或电介质溶液中很易发生可逆的解聚,解聚分子的Stoke半径在22左右,沉降系数1.8—2.8S,据此,解聚的大部分膜蛋白(包括胰岛素受体蛋白)的分子量当在15,000—30,000道尔顿之间,解聚的胰岛素受体仍保留与胰岛素特异结合的活性。 Insulin water-soluble receptor protein and most of the water-soluble membrane protein in the higher concentrations of chelating agents or dielectric solution is prone to reversible depolymerization, depolymerization molecular Stoke radius of about 22, the sedimentation coefficient of 1.8-2.8S, Accordingly, most of the depolymerized membrane proteins, including insulin receptor proteins, have a molecular weight of between 15,000 and 30,000 Daltons and the depolymerized insulin receptor retains insulin-specific binding activity.