过去5年中已报道应用甲地孕酮醋酸酯(Megestrol acetate)的硅胶皮下埋藏法可成功地控制妊娠。不过最近的动物试验中发现在使用某些孕激素(包括甲地孕酮醋酸酯)后,出现乳房小结。为此作者在一些已知无致结作用的19去甲基孕激素中进行了筛选,找出了甲地孕酮的代用品。本文报道的是一具有三个共轭双键的19去甲基孕激素药物Norgestrienone临床试验的情况,它的结构式如下: Over the past five years, it has been reported that silicone gels subcutaneously using Megestrol acetate can successfully control pregnancy. However, recent animal tests found that the use of certain progesterone (including megestrol acetate), the emergence of breast nodules. For this reason, the authors screened some of the 19 normetrogenics known to have no detrimental effects and found a replacement for megestrol. Described herein is a Norgestrienone clinical trial of 19 demethylprogestin with three conjugated double bonds, of which the structural formula is as follows: