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目的探讨沈阳地区汉族人群TCF7L2基因rs7903146多态性与2型糖尿病的相关性。方法采用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP),对203例正常个体和202例2型糖尿病患者TCF7L2基因rs7903146多态位点进行检测。结果 rs7903146的等位基因T在对照组与病例组的频率分别为2.96%和7.18%,两者之间差异有统计学意义(P<0.05)。结论沈阳地区汉族人群TCF7L2基因rs7903146位点的多态性与2型糖尿病可能具有相关性。
Objective To investigate the association between rs7903146 polymorphism of TCF7L2 gene and type 2 diabetes in Han nationality in Shenyang area. Methods The genotypes of rs7903146 polymorphism of TCF7L2 gene in 203 normal individuals and 202 type 2 diabetic patients were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequency of allele T of rs7903146 was 2.96% and 7.18% respectively in the control group and the case group, the difference was statistically significant (P <0.05). Conclusion The rs7903146 polymorphism of TCF7L2 gene in Shenyang Han population may be related to type 2 diabetes mellitus.