维生素K为一种特殊的氨基酸[γ-羧基谷氨酸(Gla)]转译后形成所必需。γ-羧基谷氨酸存在于几个与凝血有关的血浆蛋白中,并与这些蛋白质中的Gla-介导的钙离子结合,这对它们与磷脂表面的接触来说是必要的,并对其止血功能有决定性作用。1977年,Prowse与Esnouf鉴定了牛循环血浆中的另一种维生素K依赖蛋白,并将其命名为Z蛋白。存在于人类中的与牛Z蛋白类似的物质在1984年被分离出来。Z蛋白的分子结构显示与凝 Vitamin K is required for post-translational formation of a special amino acid [gamma-carboxyglutamate (Gla)]. Gamma-carboxyglutamate is present in several plasma proteins associated with coagulation and binds to Gla-mediated calcium ions in these proteins, which are essential for their contact with the phospholipid surface and their Hemostatic function has a decisive role. In 1977, Prowse and Esnouf identified another vitamin K-dependent protein in bovine circulating plasma and named it Z protein. A similar material to bovine Z protein present in humans was isolated in 1984. The molecular structure of Z protein is shown with coagulation