对－呋喃硝苯啶（Ｐ－Ｎｉｆ）是新近合成的一种药物，为钙拮抗剂硝苯啶的呋喃衍生物。本文采用微电极技术，在离体豚鼠乳头肌上，就Ｐ－Ｎｉｆ对乳头肌细胞跨膜动作电位离子流的影响进行了观察。发现３０μｍｏｌ／Ｌ的Ｐ－Ｎｉｆ可缩短快反应细胞的ＡＰＤ５０、ＡＰＤ９０及ＡＰＤ，缩短ＥＲＰ，同时明显降低慢反应动作电位的幅度和ＡＰＤ５０、ＡＰＤ９０及Ｖｍａｘ，提示Ｐ－Ｎｉｆ的作用和Ｎｉｆ相似，主要是阻断钙通道。 P-Naphthofuran (P-Nif) is a newly synthesized drug, which is a furan derivative of the calcium antagonist nifedipine. In this paper, the microelectrode technique was used to observe the effect of P-Nif on the ionospheric potential in the transmembrane action potential of papillary muscle cells in guinea pig papillary muscles. The results showed that 30μmol / L P-Nif can shorten APD50, APD90 and APD of fast response cells, shorten ERP, and significantly reduce the magnitude of slow response action potentials and APD50, APD90 and Vmax, suggesting that P-Nif acts similar to Nif, Is blocking the calcium channel.