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目的:观察虚燥更平散治疗围绝经期高血压病患者的疗效。方法:将入选的220例患者按随机数字表随机分成氯沙坦加虚燥更平散组(治疗组110例)和氯沙坦组(对照组110例)。观察两组治疗前后血压、动态血压、神经递质各指标的变化。结果:①与对照组比较,治疗组治疗后血压、24h收缩压变异(24h SSD)、24h舒张压变异(24h DSD)、白天收缩压变异(dSSD)、夜间舒张压变异(nDSD)有明显减少,其差异有统计学意义(P<0.05)。②与对照组比较,治疗组治疗后神经肽Y(NPY)有明显减少,其差异有统计学意义(P<0.05)。结论:虚燥更平散可有效降低围绝经期高血压病患者的血压及血压变异性,其机制可能与调节神经递质水平有关。
Objective: To observe the curative effect of the treatment of patients with perimenopausal hypertension with the treatment of “Yukai and Pingping San”. Methods: The selected 220 patients were randomly divided into losartan and jiaojiaoyuping scattered group (110 cases in the treatment group) and losartan group (110 cases in the control group) according to the random number table. The changes of blood pressure, ambulatory blood pressure and neurotransmitters before and after treatment were observed. Results: ① Compared with the control group, blood pressure, 24h SSD, 24h DSD, dSSD and nDSD were significantly decreased in the treatment group after treatment , The difference was statistically significant (P <0.05). ②Compared with the control group, the neuropeptide Y (NPY) in the treatment group decreased significantly, the difference was statistically significant (P <0.05). CONCLUSION: Virtual and more casual powder can effectively reduce the blood pressure and blood pressure variability in patients with perimenopausal essential hypertension, and its mechanism may be related to the regulation of neurotransmitter levels.