很多单纯的、互不相同的因素可以引起恶心或呕吐。吗丁啉作用于胃的多巴安受体,并影响与呕吐中枢相联系的化学感受器触发区的功能,增加胃的动力并且改善胃窦十二指肠的协调性(图1)。吗丁啉集聚在胃壁,其浓度可高于血浆中的浓度,这一效果增加了该药的治疗作用。 Many simple, different factors can cause nausea or vomiting. Domperidone acts on the dopa receptors of the stomach and affects the function of the chemoreceptor trigger zone associated with the vomiting center, increasing gastric motility and improving the coordination of antrum and duodenum (Fig. 1). The domperidium accumulates in the stomach wall and its concentration can be higher than that in plasma, an effect that increases the therapeutic effect of the drug.