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通过重组ＤＮＡ技术，从农抗５１０２产生菌１０－２２菌株中得到１株工程菌株ＷＨ－１，它的培养特征与出发菌株１０－２２有明显差别，前者气生菌丝白色，不吸水，基内菌丝浅黄色，可溶性色素淡黄；后者气生菌丝深灰，在大多数培养基均能吸水，基内菌丝暗柠檬色，可溶性色素淡褐。两者在２８℃和３７℃均可良好生长。菌株ＷＨ－１能产生菌株１０－２２所产生的３种５１０２抗生素，而且活性均更强，尤其是５１０２－Ⅰ几乎要高出１０倍。菌株ＷＨ－１尚能产生菌株１０－２２不产生的１种活性物质（５１０２－Ⅳ）。该活性物质只能在琼脂培养基上产生，却不能在液体培养基中得到重复
One recombinant strain WH-1 was obtained from Agrobacterium tumefaciens strain 10-22 by recombinant DNA technology. The characteristics of the strain WH-1 were different from that of the original strain 10-22. The former had a white, non-hygroscopic, The mycelium light yellow, soluble pigment light yellow; the latter aerial mycelium dark gray, in most media can absorb water, the substrate mycelium dark lemon, soluble pigment light brown. Both developed well at 28 ° C and 37 ° C. Strain WH-1 produced 3 kinds of 5102 antibiotics produced by strain 10-22, and its activity was even stronger. Especially, 5102-I was almost 10 times higher. Strain WH-1 was still able to produce one active substance (5102-IV) that strain 10-22 did not produce. The active substance can only be produced on agar but can not be duplicated in liquid medium