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Forskolin系天然植物中提取到的二萜类化合物，为腺苷酸环化酶的特异激活剂。实验发现它能下调成骨肉瘤细胞的EGF受体，抑制酪氨酸蛋白激酶活性，抑制转化生长因子α（TGFα）的基因表达，抑制3H－TdR参入DNA以及抑制细胞周期的S期，这均支持Forskolin对成骨肉瘤细胞具有抑制增殖的作用。
Forskolin is a diterpene compound extracted from natural plants and is a specific activator of adenylate cyclase. It was found that it can downregulate EGF receptors in osteosarcoma cells, inhibit tyrosine protein kinase activity, inhibit gene expression of transforming growth factor alpha (TGFα), inhibit 3H-TdR incorporation into DNA, and inhibit cell cycle S phase. Supports Forskolin to inhibit proliferation of osteosarcoma cells.