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目的：比较２种低剂量短程三联疗法根除幽门螺旋杆菌（ＨＰ）的疗效及其不良反应。方法：８６例ＨＰ阳性的消化性溃疡或糜烂性胃窦炎病人，随机分为Ａ组（４２例，男性３４例，女性８例，年龄５６±ｓ１６ａ）和Ｂ组（４４例，男性４０例，女性４例，年龄５９±１５ａ）。Ａ组以兰索拉唑３０ｍｇ，ｐｏ，ｑｄ，替硝唑５００ｍｇ及克拉霉素２５０ｍｇ，ｐｏ，ｂｉｄ，疗程７ｄ。Ｂ组以奥美拉唑２０ｍｇ，替硝唑５００ｍｇ及克拉霉素２５０ｍｇ，ｐｏ，ｂｉｄ，疗程７ｄ。疗程结束１ｍｏ后复查胃镜及ＨＰ。结果：Ａ，Ｂ２组ＨＰ根除率分别为８８％和９１％；不良反应发生率分别为１９％和１４％，但均能耐受；组间比较Ｐ＞０．０５。结论：这２种三联疗法根除ＨＰ均有良好疗效，且根除率相近，均无严重不良反应。
Objective: To compare the efficacy and adverse reactions of two kinds of low-dose short-range triple therapy in eradicating Helicobacter pylori (HP). Methods: Eighty-six patients with HP-positive peptic ulcer or erosive antral gastritis were randomly divided into group A (42 cases, 34 males, 8 females, age 56 ± s16a) and group B (44 males, 40 cases , 4 females, age 59 ± 15a). Group A with lansoprazole 30mg, po, qd, tinidazole 500mg and clarithromycin 250mg, po, bid, course of treatment 7d. Group B with omeprazole 20mg, tinidazole 500mg and clarithromycin 250mg, po, bid, treatment 7d. After the end of 1mo review endoscopy and HP. Results: The eradication rates of HP in groups A and B2 were 88% and 91%, respectively. The incidences of adverse reactions were 19% and 14%, respectively, but both were tolerable. Conclusion: The two kinds of triple therapy have good efficacy in eradication of HP, and the eradication rate is similar, no serious adverse reactions.