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目的:探讨结核分枝杆菌γ-干扰素体外释放试验(TB-IGRA)在结核病潜伏感染(LTBI)诊断中的临床价值。方法:选取2014年3月—2014年10月来我院就诊的疑似LTBI的患者30例作为观察组,另外选取同一时期来我院体检的30名健康者作为对照组,分别对以上两组进行痰涂片分析、结核菌素皮肤试验(TST)和γ-干扰素体外释放试验(TB-IGRA),比较不同方法的阳性率。结果:在观察组中,TB-IGRA的检测结果显著高于TST和痰涂片分析(P<0.05);在健康对照组中TST的检测结果高于TB-IGRA,这与研究对象曾接种过卡介苗有关。结论:TB-IGRA诊断LTBI的敏感性及特异性强,具有重要的临床应用价值,可作为LTBI诊断的重要方法之一。
Objective: To investigate the clinical value of TB-IGRA in the diagnosis of tuberculosis latent infection (LTBI). Methods: Thirty patients with suspected LTBI who visited our hospital from March 2014 to October 2014 were selected as the observation group. 30 healthy subjects from our hospital during the same period were selected as the control group. The above two groups Sputum smear analysis, tuberculin skin test (TST) and interferon gamma release test (TB-IGRA) were performed to compare the positive rates of different methods. Results: In the observation group, the results of TB-IGRA were significantly higher than that of TST and sputum smear analysis (P <0.05); in healthy controls, TST was higher than that of TB-IGRA BCG related. Conclusion: The sensitivity and specificity of TB-IGRA in the diagnosis of LTBI is of great clinical value and may be used as one of the important methods for the diagnosis of LTBI.