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目的:探讨晚期胃肠道肿瘤血瘀程度与外周血肿瘤缺氧相关蛋白之间的关系。方法:选取本院肿瘤科2012年4月1日到2013年4月10日IV期胃癌、十二指肠癌、结直肠癌患者46例,另选取同期住院的同类疾病术后无瘤患者29例,本院体检中心健康体检者19例作为对照,入院次日抽取空腹静脉血,采用ELISA法检测血管内皮生长因子(VEGF)、骨桥蛋白(OPN)、碳酸酐酶IX(CAIX)水平。结果:晚期肿瘤以及术后无瘤组患者外周血VEGF,OPN,CAIX水平均明显高于健康对照组,晚期肿瘤组与术后无瘤组之间,前者VEGF,OPN,CAIX分别是后者的1.27倍(P>0.05)、1.33倍(P<0.05)、1.48倍(P>0.05);晚期肿瘤血瘀程度重组VEGF,CAIX水平明显高于血瘀程度轻组,前者是后者的1.92倍(P<0.01)、2.70倍(P<0.01);血瘀证症候脉络瘀血、癥积程度与VEGF,OPN,CAIX水平相关,程度越重,缺氧相关蛋白水平越高。结论:晚期胃肠道肿瘤血瘀证与外周血缺氧相关蛋白VEGF,OPN,CAIX相关。
Objective: To investigate the relationship between the degree of blood stasis in advanced gastrointestinal cancer and hypoxia related protein in peripheral blood tumor. Methods: Forty-six patients with stage IV gastric cancer, duodenal cancer and colorectal cancer were selected from April 1, 2012 to April 10, 2013. Patients with the same type of disease in the same period were selected as tumor-free patients after surgery In our hospital, 19 healthy subjects were used as controls. Fasting venous blood was collected on the next day after admission. The levels of VEGF, OPN and CAIX were detected by ELISA. Results: The levels of VEGF, OPN and CAIX in peripheral blood were significantly higher in patients with advanced tumor and non-tumor after operation than those in healthy control group, advanced tumor group and non-tumor group. VEGF, OPN and CAIX were the former 1.27-fold (P> 0.05), 1.33-fold (P <0.05), 1.48-fold higher (P> 0.05); advanced stage of tumor blood stasis recombinant VEGF, CAIX levels were significantly higher than the blood stasis light group, the former is 1.92 times (P <0.01), and 2.70-fold (P <0.01). The blood stasis syndrome was associated with venous blood stasis and the degree of symptomatology were related to the levels of VEGF, OPN and CAIX. The more severe the hypoxia-related protein was, Conclusion: The blood-stasis syndrome in patients with advanced gastrointestinal cancer is associated with hypoxia-related protein VEGF, OPN and CAIX in peripheral blood.