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目的:对米索前列醇联合缩宫素在预防产后出血中的效果与价值进行观察分析。方法:选取我院自2012年5月~2013年10月期间,门诊部所收治的产妇共计100例作为研究对象,按照数字随机表方法进行分组,形成对照组、观察组,每组患者各计50例。对照组50例产妇仅给予缩宫素治疗,观察组50例产妇给予米索前列醇联合缩宫素的治疗方案。对两组产妇的产程以及产后出血情况进行综合观察对比。结果:观察组、对照组产妇第一产程时间、第二产程时间对比无明显差异,P>0.05,不具有统计学意义。观察组第三产程时间为(7.2±1.8)min,明显短于对照组(16.2±2.5)min,产后30min内平均出血量、2h内平均出血量均明显低于对照组,产后出血发生率为4.00%(2/50),明显低于对照组20.00%(10/50),数据对比差异显著,P<0.05,具有统计学意义。结论:米索前列醇联合缩宫素预防产后出血效果确切,可缩短产妇第三产程时间,降低产后出血量以及出血发生率,安全性高,可作为预防产后出血的常规用药方案。
Objective: To observe and analyze the effect and value of misoprostol combined with oxytocin in preventing postpartum hemorrhage. Methods: A total of 100 maternal women admitted to our hospital from May 2012 to October 2013 were selected as the research objects and grouped according to the digital random table method to form the control group, the observation group and the patients in each group 50 cases. 50 women in the control group were treated with oxytocin only and 50 women in the observation group were treated with misoprostol combined with oxytocin. The two groups of maternal labor process and postpartum hemorrhage were observed and compared. Results: There was no significant difference between the observation group and the control group in the time of the first stage of labor and the second stage of labor, P> 0.05, not statistically significant. The duration of the third stage of labor in the observation group was (7.2 ± 1.8) min, which was significantly shorter than that in the control group (16.2 ± 2.5) min. The average amount of bleeding within 30 minutes and the average amount of bleeding within 2 hours were significantly lower in the observation group. The incidence of postpartum hemorrhage was 4.00% (2/50) respectively, which was significantly lower than that of the control group (20.00%, 10/50). There was significant difference between the two groups (P <0.05). Conclusion: Misoprostol combined with oxytocin is effective in preventing postpartum hemorrhage. It can shorten the duration of the third stage of labor, reduce the amount of postpartum hemorrhage and the incidence of hemorrhage. It is safe and can be used as a routine medication for preventing postpartum hemorrhage.