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一、甲状腺制剂的药动学基础三碘甲状腺原氨酸(T_3)口服后90%由胃肠道吸收,入血后与血浆蛋白结合的较松驰,游离型较多,故作用快而强。T_3的生物学效应比T_4强2.5～3倍.T_3口服吸收很快,两小时后血中浓度达高峰.血中半衰期为1.4天,排泄较快,故作用维持时间较短.四碘甲状腺原氯酸(T_4)口服后40～75%经胃肠道吸收,入血后与血浆蛋白结合牢固,游离型较少,所以作用发生较慢。每天仅有10%的T_4被代谢,因此T_4作用维持时间较长,正常人T_4的血浆半衰期为6～7天;甲低时9～10天,甲亢者3～4天。由
First, the basis of pharmacokinetics of thyroid preparations Triiodothyronine (T_3) after oral administration of 90% absorbed by the gastrointestinal tract into the blood plasma protein binding more relaxed, free more, so fast and strong . The biological effect of T_3 is 2.5 ~ 3 times stronger than that of T_4.T_3 orally absorbed quickly, and the blood concentration peaked after two hours.The blood half-life was 1.4 days and excreted fast, so the effect of maintaining time is short. Chloramphenicol (T_4) after oral administration of 40 to 75% absorbed by the gastrointestinal tract, into the blood and plasma protein binding firm, less free, so the role of slower. Only 10% of T_4 is metabolized each day, so the role of T_4 to maintain a longer time, normal plasma T_4 half-life of 6 to 7 days; hypothyroidism 9 to 10 days, hyperthyroidism 3 to 4 days. by