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本文作者继1967年创立了一种评价鼠疟病因性预防药物的简单的生物试验方法后,于1975年又将方法作了改进。新方法为:实验组和对照组各用6只19天龄的雌性大白鼠,试验组和对照组各用4只大白鼠静脉注入从斯氏按蚊涎腺取得的伯氏疟原虫子孢子1万个,另2只注入25万个。试验组在感染当天和前一天投药,一天两次,总剂量最初选用640毫克,或选用至少能使4只动物存活48小时的剂量。如有病因性预防作用,就
After a simple biological test for evaluating the etiological prophylaxis against murine malaria was established in 1967, the authors modified the method in 1975. The new method was as follows: Six 19-day-old female rats were used in the experimental group and the control group, and four rats in the experimental group and the control group were intravenously injected with P. berghei sporozoite 1 Million, the other two injected 250,000. The test group was dosed twice a day on the day of infection and the day before, with a total dose of 640 mg initially, or a dose of at least 4 hours of survival for 48 hours. If the cause of preventive effect, it