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背景:迟发性维生素K缺乏症至今仍然是全世界值得重视的问题,如何有效地预防此病的发生目前有不同的观点。目的:监测血浆中维生素K缺乏诱导蛋白(proteininducedbyvitaminKabsence,PIVKA-Ⅱ)的水平,探讨预防迟发性维生素K缺乏症的最佳方案。设计:采用随机对照研究方法。地点和对象:由河南省妇幼保健院负责收集1999-05/2000-12在新密市妇幼保健院出生的79例(男40例,女39例;平均胎龄39.3周;平均体质量3516g)婴儿血浆,送至北京医科大学和首都儿研所分别检测血浆中维生素K含量和维生素K缺乏诱导蛋白的水平。方法:将婴儿随机分成乳母口服干预组和婴儿口服干预组,乳母口服干预组自婴儿出生后乳母每周口服维生素K110mg,共10次,婴儿口服干预组为婴儿出生后每周口服维生素K1,剂量和次数与乳母口服干预组相同。维生素K含量和血浆PIVKA-Ⅱ阳性率分别采用高压液相色谱分析法和酶联免疫吸附法进行检测。主要观察指标:①乳母口服维生素K1干预组与对照组乳汁维生素K含量比较。②婴儿、乳母口服维生素K1干预组与对照组血浆PIVKA-Ⅱ阳性率比较。结果:乳母口服干预组在1个月、2个月时母乳中维生素K含量显著高于对照组(P<0.05),但婴儿1个月时血浆中PIVKA-Ⅱ阳性率与对照组差异无显著性意义(χ2=1.762,P>0.05);婴儿口服干预组?
BACKGROUND: Delayed vitamin K deficiency is still an important issue in the world so far. There are different views on how to effectively prevent the occurrence of this disease. Objective: To monitor the level of plasma induced protein kinase C (PIVKA-Ⅱ) and to explore the best way to prevent delayed vitamin K deficiency. Design: Randomized controlled study. Place and Subject: The Maternal and Child Health Hospital of Henan province collected 79 cases (40 males and 39 females; average gestational age 39.3 weeks; average body weight 3516g) born in Xinmi City MCH from 1999-05 to 2000-12. Infant plasma was sent to Beijing Medical University and Beijing Capital Institute for detection of plasma vitamin K levels and vitamin K deficiency-induced protein levels. Methods: The infants were randomly divided into two groups: oral intervention group and infant oral intervention group. The oral administration group received 10 mg vitamin K110 weekly, and the oral intervention group was oral vitamin K1 once a week And the same number of times and breast milk oral intervention group. Vitamin K content and plasma PIVKA-Ⅱ positive rate were detected by high pressure liquid chromatography and enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES: ①Comparison of milk vitamin K content in milk extract oral vitamin K1 intervention group and control group. ② The positive rates of plasma PIVKA-Ⅱ in infants and lactating maternal oral vitamin K1 intervention group and the control group were compared. Results: At 1 month and 2 months, the vitamin K content in breast milk was significantly higher than that in the control group (P <0.05). However, there was no significant difference in the positive rate of PIVKA-Ⅱ between the infants and the control group Sexual significance (χ2 = 1.762, P> 0.05); infant oral intervention group?