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目的探讨无创正压通气治疗慢性阻塞性肺疾病(COPD)并发慢性呼吸衰竭患者的疗效。方法对住院8例稳定期COPD并发慢性呼吸衰竭患者采用BiPAP呼吸机经鼻/面罩无创正压通气治疗,4h/次,2次/d,连续2个月。治疗前后对动脉血气及肺通气功能进行检测,并进行统计学分析。结果动脉血气治疗前后PaCO2分别为(61.837±18.214)mmHg和(40.013±1.768)mmHg,PaO2分别为(44.125±11.679)mmHg和(76.000±9.970)mmHg、SaO2分别为(72.125±12.789)%和(91.750±3.410)%,差异有统计学意义(P<0.05);肺功能治疗前后FEV1分别为(18.00±4.36)%和(34.67±8.96)%、FEV1/FVC分别为(43.67±2.52)%和(55.00±4.58)%,差异有统计学意义(P<0.05)。结论无创正压通气治疗缓解期COPD呼吸衰竭患者可改善肺通气功能,改善患者缺氧情况及降低动脉血气CO2潴留,是一个值得推荐的治疗方法。
Objective To investigate the curative effect of noninvasive positive pressure ventilation on patients with chronic obstructive pulmonary disease (COPD) complicated with chronic respiratory failure. Methods 8 cases of stable COPD patients with chronic respiratory failure were treated with BiPAP ventilator nasal / mask noninvasive positive pressure ventilation for 4h / time, 2 times / d for 2 months. Before and after treatment of arterial blood gas and pulmonary ventilation were detected and statistical analysis. Results PaCO2 before and after arterial blood gas treatment were (61.837 ± 18.214) mmHg and (40.013 ± 1.768) mmHg respectively, and PaO2 were (44.125 ± 11.679) mmHg and (76.000 ± 9.970) mmHg respectively, and SaO2 were (72.125 ± 12.789)% and 91.750 ± 3.410)% respectively, the difference was statistically significant (P <0.05); FEV1 was (18.00 ± 4.36)% and (34.67 ± 8.96)% respectively before and after pulmonary function therapy, and the FEV1 / FVC were (43.67 ± 2.52)% and (55.00 ± 4.58)%, the difference was statistically significant (P <0.05). Conclusion Noninvasive positive pressure ventilation in remission patients with COPD can improve pulmonary ventilation, improve hypoxia and reduce arterial blood gas CO2 retention, which is a recommendable treatment.