【摘 要】
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Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons.Here,we repo
【机 构】
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Department of Neurobiology and Department of Neuro-surgery of the First Affiliated Hospital,Zhejiang
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Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons.Here,we report the C.elegans outer labial lateral(OLL)sensilla sensory neurons respond to touch and cold.Mechanosen-sation of OLL neurons resulted in cell-autonomous mechanically-evoked Ca2+transients and rapidly-adapting mechanoreceptor currents with a very short latency.Mechanotransduction of OLL neurons might be carried by a novel Na+conductance channel,which is insensitive to amiloride.The bona fide mechano-gated Na+-selective degenerin/epithelial Na+channels,TRP-4,TMC,and Piezo proteins are not involved in this mechanosensation.Interestingly,OLL neurons also mediated cold but not warm responses in a cell-autonomous manner.We further showed that the cold response of OLL neurons is not mediated by the cold receptor TRPA-1 or the temperature-sensitive glutamate receptor GLR-3.Thus,we propose the polymodal functionality of OLL neurons in mechanosen-sation and cold sensation.
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