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目的:了解我院2012年儿童药品不良反应(ADR)发生的特点和规律,为儿童安全、有效、合理用药提供依据。方法:从我院2012年上报国家药品不良反应监测中心的全部ADR报告中,筛选出14岁及以下儿童患者的ADR报告进行统计分析。结果:2012年我院儿童ADR多发于学龄前,且高发于原患疾病为呼吸系统感染的患儿。引起ADR的药物以抗菌药物为主,抗菌药物注射剂和口服中成药引起的ADR多见;累及器官或系统以皮肤损害多见,其次是胃肠道损害。结论:临床医师应关注儿童患者抗菌药物的合理使用,警惕中成药口服引起的ADR。我院儿童用药的规范性和合理性仍有待进一步加强。
Objective: To understand the characteristics and laws of 2012 ADR in our hospital and provide the basis for safe, effective and rational drug use. Methods: According to the ADR reports from our hospital in 2012 to the National Adverse Drug Reaction Monitoring Center, the ADRs of children aged 14 years and younger were screened out for statistical analysis. Results: In 2012, children with ADR in our hospital were predominantly preschool and had high incidence of children with respiratory tract infection. The drugs that cause ADR are mainly antibacterial drugs. ADR caused by antibiotic injection and oral proprietary Chinese medicine is more common. The skin lesions involving organs or systems are more common, followed by gastrointestinal damage. Conclusion: Clinicians should pay attention to the rational use of antibiotics in children and be alert to ADR caused by oral administration of proprietary Chinese medicines. Children’s medicine in our hospital normative and reasonable still needs to be further strengthened.