滤泡辅助性T细胞(follicular helper T cells,Tfh)作为一种新发现的CD4+T细胞亚群,其主要功能是辅助B细胞增殖、分化、产生抗体,参与体液免疫应答。由于Tfh细胞在体液免疫应答中的重要作用,近年来成为研究的热点。现将概述Tfh细胞的发现、分化过程、相关的调控分子,及其在病毒感染性疾病中的研究进展。 Follicular helper T cells (Tfh) as a newly discovered subpopulation of CD4 + T cells, its main function is to assist B cell proliferation, differentiation, antibody production, involved in the humoral immune response. Due to the important role of Tfh cells in humoral immune response, it has become a hot spot in recent years. We will now outline the discovery of Tfh cells, the process of differentiation, related regulatory molecules, and their advances in viral infectious diseases.